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Article

B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2016

Klotz Luisa, Kuzmanov Ivan, Hucke Stephanie, Gross Catharina C, Posevitz Vilmos, Dreykluft Angela, Schulte-Mecklenbeck Andreas, Janoschka Claudia, Lindner Maren, Herold Martin, Schwab Nicholas, Ludwig-Portugall Isis, Kurts Christian, Meuth Sven G, Kuhlmann Tanja, Wiendl Heinz

Abstract excerpt

Molecular mechanisms that determine lesion localization or phenotype variation in multiple sclerosis are mostly unidentified. Although transmigration of activated encephalitogenic T cells across the blood-brain barrier (BBB) is a crucial step in the disease pathogenesis of CNS autoimmunity, the consequences on brain endothelial barrier integrity upon interaction with such T cells and subsequent lesion formation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Encephalomyelitis, Autoimmune, Experimental

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Source

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Identifiers

PMID: 27671636
DOI: 10.1073/pnas.1601350113
PMCID: PMC5068266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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