Article

GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohn’s disease

2026-02-05

Abstract excerpt

Macrophage (M-), granulocyte (G-), and granulocyte–macrophage (GM-) colony-stimulating factors (CSFs) regulate myeloid cell function, yet their relative roles during inflammation remain poorly defined. To uncover how CSFs shape spatial immune niches in Crohn’s disease, we performed Xenium single-cell spatial transcriptomics on ileal tissues, revealing cell-type–specific expression and source–target interactions fo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cdb87d72-a22e-573a-80f3-2f7d5a1ec84f
DOI: 10.64898/2026.02.03.703526

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohn’s diseaseDOI 10.64898/2026.02.03.703526Read

GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.Semantic proximity Read

Regional Cell Atlas of Human Intestine Shapes Distinct Immune SurveillanceSemantic proximity Read

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodelingSemantic proximity Read

Epithelia mediate inflammation with myeloid cells in Crohn’s disease patients under treatmentSemantic proximity Read

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolutionSemantic proximity Read

Spatiotemporal single cell transcriptomic analysis of human gut macrophages reveals multiple functional and niche-specific subsetsSemantic proximity Read

Landscape of mast cell populations across organs in mice and humansSemantic proximity Read

Cells of the human intestinal tract mapped across space and timeSemantic proximity Read

New Insight into Intestinal Mast Cells Revealed by Single-Cell RNA SequencingSemantic proximity Read

DNAM-1 immunoreceptor integrates innate and adaptive immune programs to drive intestinal inflammationSemantic proximity Read

An image-based transcriptomics atlas reveals the regional and microbiota-dependent molecular, cellular, and spatial structure of the murine gutSemantic proximity Read

Commensal microbiota drive the functional diversification of colon macrophages.Semantic proximity Read