Article

DNAM-1 immunoreceptor integrates innate and adaptive immune programs to drive intestinal inflammation

2026-04-01

Abstract excerpt

<h4>Summary</h4> Innate and adaptive immune responses play critical roles in the pathogenesis of inflammatory bowel disease (IBD), yet the molecular pathways integrating these responses remain elusive. Here, we identify DNAM-1 immunoreceptor as a central driver of colitis through distinct, cell type–specific mechanisms. Transcriptomic analyses of human and murine group 3 innate lymphoid cells (ILC3s) revealed DNA...

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Literature Corpus work: 827e3122-ced1-50fd-8cfa-2e236a2a6831
DOI: 10.64898/2026.03.30.715436

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