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Article

GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.

Cell reports - 7 Jul 2020

Castro-Dopico Tomas, Fleming Aaron, Dennison Thomas W, Ferdinand John R, Harcourt Katherine, Stewart Benjamin J, Cader Zaeem, Tuong Zewen K, Jing Chenzhi, Lok Laurence S C, Mathews Rebeccah J, Portet Anaïs, Kaser Arthur, Clare Simon, Clatworthy Menna R

Abstract excerpt

Macrophages play a central role in intestinal immunity, but inappropriate macrophage activation is associated with inflammatory bowel disease (IBD). Here, we identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical regulator of intestinal macrophage activation in patients with IBD and mice with dextran sodium sulfate (DSS)-induced colitis. We find that GM-CSF drives the maturation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32640223
DOI: 10.1016/j.celrep.2020.107857
PMCID: PMC7351110

Genes

CSF2

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