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Landscape of mast cell populations across organs in mice and humans

27 Jun 2023

Abstract excerpt

Mast cells (MCs) are tissue-resident immune cells that exhibit homeostatic and neuron-associated functions. Here, we combined whole-tissue imaging and single-cell RNA sequencing datasets to generate a pan-organ analysis of MCs in mice and humans at steady state. In mice, we identify two mutually exclusive MC populations, MrgprB2+ connective tissue-type MCs and MrgprB2neg mucosal-type MCs, with specific...

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PMID: 37462672
DOI: 10.1084/jem.20230570

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