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Article

Commensal microbiota drive the functional diversification of colon macrophages.

Mucosal immunology - 1 Mar 2020

Kang Byunghyun, Alvarado Luigi J, Kim Teayong, Lehmann Michael L, Cho Hyeseon, He Jianping, Li Peng, Kim Bong-Hyun, Larochelle Andre, Kelsall Brian L

Abstract excerpt

Mononuclear phagocytes are a heterogeneous population of leukocytes essential for immune homeostasis that develop tissue-specific functions due to unique transcriptional programs driven by local microenvironmental cues. Single cell RNA sequencing (scRNA-seq) of colonic myeloid cells from specific pathogen free (SPF) and germ-free (GF) C57BL/6 mice revealed extensive heterogeneity of both colon macrophages (MPs)...

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Identifiers

PMID: 31772323
DOI: 10.1038/s41385-019-0228-3
PMCID: PMC7039809

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CCR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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