Article

MAPK13 controls structural remodeling and disease after epithelial injury

2024-06-03

Abstract excerpt

All living organisms are charged with repair after injury particularly at epithelial barrier sites, but in some cases this response leads instead to structural remodeling and long-term disease. Identifying the molecular and cellular control of this divergence is key to disease modification. In that regard, stress kinase control of epithelial stem cells is a rational entry point for study. Here we examine the poten...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd83f631-2cfd-5286-a8d8-9219e5a41360
DOI: 10.1101/2024.05.31.596863

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MAPK13 controls structural remodeling and disease after epithelial injuryDOI 10.1101/2024.05.31.596863Read

A first-in-kind MAPK13 inhibitor corrects stem cell reprogramming and muco-obstructive lung diseaseSemantic proximity Read

A potent MAPK13-14 inhibitor prevents airway inflammation and mucus productionSemantic proximity Read

A Goldilocks principle of JAK/STAT signaling governs airway epithelial homeostasis and stress adaptation in <i>Drosophila</i>Semantic proximity Read

Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling following Respiratory Viral InfectionSemantic proximity Read

SARS-CoV-2 PLpro Hijacks a Conserved Stress Signaling Network to Drive Organ-Specific Loss of Epithelial HomeostasisSemantic proximity Read

Airway injury induces alveolar epithelial responses mediated by macrophagesSemantic proximity Read

An injury-induced tissue niche shaped by mesenchymal plasticity coordinates the regenerative and disease response in the lungSemantic proximity Read

Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling following Respiratory Viral Infection.Semantic proximity Read

Disruption of E-cadherin in the airway led to dysplastic stressed cells and asthma-like phenotypes.Semantic proximity Read

STAT3 mutation-associated airway epithelial defects in Job syndrome.Semantic proximity Read

JNK integrates immune and stress signals to balance apoptosis and proliferation in airway progenitorsSemantic proximity Read

Sorted-Cell Proteomics Reveals an AT1-Associated Epithelial Cornification Phenotype and Suggests Endothelial Redox Imbalance in Human Bronchopulmonary DysplasiaSemantic proximity Read