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Article

STAT3 mutation-associated airway epithelial defects in Job syndrome.

The Journal of allergy and clinical immunology - 1 Aug 2023

Zhang Yihan, Lin Tian, Leung Hui Min, Zhang Cheng, Wilson-Mifsud Brittany, Feldman Michael B, Puel Anne, Lanternier Fanny, Couderc Louis-Jean, Danion Francois, Catherinot Emilie, Salvator Hélène, Tcherkian Colas, Givel Claire, Xu Jie, Tearney Guillermo J, Vyas Jatin M, Li Hu, Hurley Bryan P, Mou Hongmei

Abstract excerpt

BACKGROUND: Job syndrome is a disease of autosomal dominant hyper-IgE syndrome (AD-HIES). Patients harboring STAT3 mutation are particularly prone to airway remodeling and airway infections. OBJECTIVES: Airway epithelial cells play a central role as the first line of defense against pathogenic infection and express high levels of STAT3. This study thus interrogates how AD-HIES STAT3 mutations impact the...

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Source

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Identifiers

PMID: 36638921
DOI: 10.1016/j.jaci.2022.12.821
PMCID: PMC10330947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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