Article

SARS-CoV-2 PLpro Hijacks a Conserved Stress Signaling Network to Drive Organ-Specific Loss of Epithelial Homeostasis

2026-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Severe SARS-CoV-2 infection manifests as a systemic disorder characterized by catastrophic loss of epithelial homeostasis and dysregulated host inflammation. However, which specific viral factors initiate this tissue damage in intact, living organisms remains unresolved. Using a comprehensive in vivo screen of all 25 SARS-CoV-2 nonstructural proteins (NSPs) and accessory factors (ORFs) in the...

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Literature Corpus work: 49cbd112-5ebf-527e-b7f1-b990a0b95d11
DOI: 10.64898/2026.03.24.713966

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