Article
Disruption of E-cadherin in the airway led to dysplastic stressed cells and asthma-like phenotypes.
Developmental cell - 17 Nov 2025
Young Randee E, Lee Sunyoung, Chin Jisun, Dash Barsha, Sahi Jugraj, Nantie Leah B, Su Yujuan, Salamon Rebecca J, Verheyden Jamie M, Barr Justinn, Shin Jae Woo, Day Andrew S H, Vijayanand Pandurangan, Reyes de Barboza Nabora, Sun Xin
Abstract excerpt
While E-cadherin is a known core component of the adherens junction, how it controls cell fate remains poorly understood. Here, we show that in the mouse airway, inactivation of E-cadherin in epithelial progenitor club cells, but not terminally differentiated ciliated cells, led to increased proliferation, goblet cell metaplasia, and immune infiltration, mimicking asthma phenotypes without exposure to allergen....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.