Article

Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling following Respiratory Viral Infection

2021-09-22

Abstract excerpt

<h4>Summary</h4> Epithelial plasticity has been suggested in lungs of mice following genetic depletion of stem cells but is of unknown physiological relevance. Viral infection and chronic lung disease share similar pathological features of stem cell loss in alveoli, basal cell (BC) hyperplasia in small airways, and innate immune activation, that contribute to epithelial remodeling and loss of lung function. We sh...

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Literature Corpus work: 1afd5f1d-a78e-57fc-a581-7358f2c87ebf
DOI: 10.1101/2021.09.22.461381

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