Article

JNK integrates immune and stress signals to balance apoptosis and proliferation in airway progenitors

2025-10-31

Abstract excerpt

Chronic inflammation disrupts epithelial regeneration, yet how immune signaling reprograms progenitor fate remains unclear. Using the Drosophila airway as a model of epithelial remodeling, we identify the c-Jun N-terminal kinase (JNK) pathway as a central integrator of immune and stress cues that balances apoptosis and compensatory proliferation in airway progenitors. Persistent activation of the innate immune IM...

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Identifiers and source

Literature Corpus work: 3092f584-4e4e-5bfa-ae3e-d742cc3fc97d
DOI: 10.1101/2025.10.30.685523

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