Article

An injury-induced tissue niche shaped by mesenchymal plasticity coordinates the regenerative and disease response in the lung

2024-02-29

Abstract excerpt

Severe lung injury causes basal stem cells to migrate and outcompete alveolar stem cells resulting in dysplastic repair and a loss of gas exchange function. This “stem cell collision” is part of a multistep process that is now revealed to generate an i njury-induced t issue ni ch e (iTCH) containing Keratin 5+ epithelial cells and plastic Pdgfra+ mesenchymal cells. Temporal and spatial single cell analysis reve...

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Literature Corpus work: de78fcaf-7aee-5007-8ad4-509b0204df87
DOI: 10.1101/2024.02.26.582147

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