Article

A first-in-kind MAPK13 inhibitor corrects stem cell reprogramming and muco-obstructive lung disease

2024-08-22

Abstract excerpt

The stress kinase MAPK13 (aka p38delta-MAPK) is an attractive entry point for therapeutic intervention because it regulates the structural remodeling that can develop after epithelial injury in the lung and likely other tissue sites. However, a selective, safe, and effective MAPK13 inhibitor is not yet available for experimental or clinical application. Here we identify a first-in-kind MAPK13 inhibitor using struc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de3b08e4-74ce-5959-b6ab-24535bbd2911
DOI: 10.1101/2024.08.21.608990

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A first-in-kind MAPK13 inhibitor corrects stem cell reprogramming and muco-obstructive lung diseaseDOI 10.1101/2024.08.21.608990Read

MAPK13 controls structural remodeling and disease after epithelial injurySemantic proximity Read

A potent MAPK13-14 inhibitor prevents airway inflammation and mucus productionSemantic proximity Read

Precision drugging of the MAPK pathway in head and neck cancerSemantic proximity Read

Role and regulation of MKP-1 in airway inflammationSemantic proximity Read

A Goldilocks principle of JAK/STAT signaling governs airway epithelial homeostasis and stress adaptation in <i>Drosophila</i>Semantic proximity Read

NFKB1/NR3C1-MAPK4 axis regulates the pathology of acute lung injurySemantic proximity Read

SARS-CoV-2 PLpro Hijacks a Conserved Stress Signaling Network to Drive Organ-Specific Loss of Epithelial HomeostasisSemantic proximity Read

Clinical Potential of Misshapen/NIKs-Related Kinase (MINK) 1—A Many-Sided Element of Cell Physiology and PathologySemantic proximity Read

A cell-based drug discovery assay identifies inhibition of cell stress responses as a new approach to treatment of epidermolysis bullosa simplex.Semantic proximity Read

Targeting AKAP13 RhoGEF activity ameliorates pro-fibrotic phenotypes driven by the IPF associated <i>AKAP13</i> risk variantSemantic proximity Read

STAT3 Gain of Function: A New Kid on the Block in Interstitial Lung DiseasesSemantic proximity Read

Computational AOP modeling links 1-nitropyrene exposure to asthma exacerbation and COPD progressionSemantic proximity Read