Article
A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.
Molecular and cellular neurosciences - 1 Nov 2007
Xu Pu-Ting, Li Yi-Ju, Qin Xue-Jun, Kroner Charles, Green-Odlum Anya, Xu Hong, Wang Tian-Yuan, Schmechel Donald E, Hulette Christine M, Ervin John, Hauser Mike, Haines Jonathan, Pericak-Vance Margaret A, Gilbert John R
Abstract excerpt
APOE4 allele is a major risk factor for late-onset Alzheimer disease (AD). The mechanism of action of APOE in AD remains unclear. To study the effects of APOE alleles on gene expression in AD, we have analyzed the gene transcription patterns of human hippocampus from APOE3/3, APOE3/4, APOE4/4 AD patients and normal control using Serial Analysis of Gene Expression (SAGE). Using SAGE, we found gene expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.