Article

Comprehensive analysis of clustered mutations in cancer reveals recurrent APOBEC3 mutagenesis of ecDNA

2021-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Clustered somatic mutations are common in cancer genomes with prior analyses revealing several types of clustered single-base substitutions, including doublet- and multi-base substitutions, diffuse hypermutation termed omikli , and longer strand-coordinated events termed kataegis . Here, we provide a comprehensive characterization of clustered substitutions and clustered small insertions and d...

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Literature Corpus work: 25ff4301-9a18-5cfd-8af9-ec3f854c3475
DOI: 10.1101/2021.05.27.445689

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