Article

The retinoblastoma tumor suppressor limits ribosomal readthrough during oncogene induced senescence

2019-10-01

Abstract excerpt

The origin and evolution of cancer cells is considered to be mainly fueled by mutations affecting the DNA sequence. Although errors in translation could also expand the cellular proteome, their role in cancer biology remains poorly understood. Tumor suppressors called “caretakers” block cancer initiation and progression by preventing DNA mutations and/or stimulating DNA repair. If translational errors contribute t...

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Literature Corpus work: cd598d8c-32db-5fc1-96cc-61761647b92a
DOI: 10.1101/788380

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