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Article

A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence.

Molecular and cellular biology - 1 Feb 2010

Talluri Srikanth, Isaac Christian E, Ahmad Mohammad, Henley Shauna A, Francis Sarah M, Martens Alison L, Bremner Rod, Dick Frederick A

Abstract excerpt

Terminally differentiated cell types are needed to live and function in a postmitotic state for a lifetime. Cellular senescence is another type of permanent arrest that blocks the proliferation of cells in response to genotoxic stress. Here we show that the retinoblastoma protein (pRB) uses a mec...

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Identifiers

PMID: 20008551
DOI: 10.1128/MCB.01168-09
PMCID: PMC2815577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20008551-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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