Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular senescence limits translational readthrough.

Biology open - 1 Dec 2021

Del Toro Neylen, Lessard Frédéric, Bouchard Jacob, Mobasheri Nasrin, Guillon Jordan, Igelmann Sebastian, Tardif Sarah, Buffard Tony, Bourdeau Véronique, Brakier-Gingras Léa, Ferbeyre Gerardo

Abstract excerpt

The origin and evolution of cancer cells is considered to be mainly fueled by DNA mutations. Although translation errors could also expand the cellular proteome, their role in cancer biology remains poorly understood. Tumor suppressors called caretakers block cancer initiation and progression by preventing DNA mutations and/or stimulating DNA repair. If translational errors contribute to tumorigenesis, then...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Biosynthesis

Source

Open in PubMed Open full text

Identifiers

PMID: 34676390
DOI: 10.1242/bio.058688
PMCID: PMC8649927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular senescence limits translational readthrough.PMID 34676390Read ↗

The retinoblastoma tumor suppressor limits ribosomal readthrough during oncogene induced senescenceSemantic proximity Read ↗

Translational Control during Cellular Senescence.Semantic proximity Read ↗

Senescence suppresses the integrated stress response and activates a stress-enhanced secretory phenotypeSemantic proximity Read ↗

The Translatome of Senescent Cells Revealed by Sequencing Actively Translated mRNASemantic proximity Read ↗

Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough.Semantic proximity Read ↗

Control of Gene Expression in Senescence through Transcriptional Read-Through of Convergent Protein-Coding GenesSemantic proximity Read ↗

Position-Dependent NMD Generates Diverse Protein OutcomesSemantic proximity Read ↗

Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responsesSemantic proximity Read ↗

Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality controlSemantic proximity Read ↗

Bacterial senescence: protein oxidation in non-proliferating cells is dictated by the accuracy of the ribosomes.Semantic proximity Read ↗

TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast.Semantic proximity Read ↗

Translational efficiency across healthy and tumor tissues is proliferation-relatedSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.