Article

Translatome and translation dynamics analysis of a RiboCancer cell line panel reveals that leukemia-associated Rps15 mutations rewire translation through codon-specific tRNA accommodation defects

2025-11-18

Abstract excerpt

<h4>ABSTRACT</h4> Deletions and point mutations targeting ribosomal proteins (RPs) have been identified in cancer. Yet, their role in translational dysregulation remains poorly understood. We performed an integrated genome-wide translatome analysis (proteome, Ribo-seq and total RNA-seq) as well as RiboMethSeq on an isogenic cell line library modeling the most recurrent RP defects in cancer (Rpl5 +/− , Rpl11 +/−...

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Literature Corpus work: d0a23e83-6e3a-55c9-ab24-43c341d9366a
DOI: 10.1101/2025.11.18.687986

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