Article
How Ribosomes Translate Cancer.
Cancer discovery - 1 Oct 2017
Sulima Sergey O, Hofman Isabel J F, De Keersmaecker Kim, Dinman Jonathan D
Abstract excerpt
A wealth of novel findings, including congenital ribosomal mutations in ribosomopathies and somatic ribosomal mutations in various cancers, have significantly increased our understanding of the relevance of ribosomes in oncogenesis. Here, we explore the growing list of mechanisms by which the ribosome is involved in carcinogenesis-from the hijacking of ribosomes by oncogenic factors and dysregulated translational...
Topics
- Animals
- Disease Progression
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Humans
- Mutation
- Neoplasms
- Ribosomal Proteins