Article

TTF1 control of LncRNA synthesis and cell growth delineates a tumour suppressor pathway acting directly on the ribosomal RNA Genes

2024-02-11

Abstract excerpt

<h4>ABSTRACT</h4> The tumour suppressor p14/19ARF regulates ribosomal RNA (rRNA) synthesis by controlling the nucleolar localization of Transcription Termination Factor 1 (TTF1). However, the role played by TTF1 in regulating the rRNA genes and in potentially controlling growth has remained unclear. We now show that TTF1 expression regulates cell growth by determining the cellular complement of ribosomes. Unexpec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 263d0e44-e52f-5fc2-b395-f8d4417f498c
DOI: 10.1101/2024.02.11.579707

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TTF1 control of LncRNA synthesis and cell growth delineates a tumour suppressor pathway acting directly on the ribosomal RNA GenesDOI 10.1101/2024.02.11.579707Read

Dynamic regulation and requirement for ribosomal RNA transcription during mammalian developmentSemantic proximity Read

Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylationSemantic proximity Read

The retinoblastoma tumor suppressor limits ribosomal readthrough during oncogene induced senescenceSemantic proximity Read

Ribosome Biogenesis and Function in Cancer: From Mechanisms to TherapySemantic proximity Read

Control of Ribosomal RNA Synthesis by Hematopoietic Transcription FactorsSemantic proximity Read

Chromatin topology control by a muscle-specific ribosomal proteinSemantic proximity Read

Bidirectional cooperation between Ubtf1 and SL1 determines RNA Polymerase I promoter recognition <i>in cell</i> and is negatively affected in the UBTF-E210K neuroregression syndromeSemantic proximity Read

Superabundant microRNAs are transcribed from human rDNA spacer promoters insulated by CTCFSemantic proximity Read

Translational control in cancer etiology.Semantic proximity Read

The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF.Semantic proximity Read

Dynamic regulation and requirement for ribosomal RNA transcription during mammalian developmentSemantic proximity Read

Diversity of ribosomes at the level of rRNA variation associated with human health and diseaseSemantic proximity Read