Article

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

2020-12-09

Abstract excerpt

While aggregation-prone proteins are known to accelerate ageing and cause age-related diseases, the cellular mechanisms that drive their cytotoxicity remain unresolved. The orthologous proteins MOAG-4, SERF1A and SERF2 have recently been identified as cellular modifiers of such cytotoxicity. Using a peptide array screening approach on human amyloidogenic proteins, we found that SERF2 interacted with specific patte...

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Literature Corpus work: cd564835-2ab6-5f79-bd2d-67003010fc7f
DOI: 10.1101/2020.12.09.417709

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