Article
Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans.
Scientific reports - 13 Jul 2021
Perni Michele, Mannini Benedetta, Xu Catherine K, Kumita Janet R, Dobson Christopher M, Chiti Fabrizio, Vendruscolo Michele
Abstract excerpt
Misfolded protein oligomers are increasingly recognized as highly cytotoxic agents in a wide range of human disorders associated with protein aggregation. In this study, we assessed the possible uptake and resulting toxic effects of model protein oligomers administered to C. elegans through the culture medium. We used an automated machine-vision, high-throughput screening procedure to monitor the phenotypic...
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