Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan.

Abstract excerpt

Genetic studies indicate that protein homeostasis is a major contributor to metazoan longevity. Collapse of protein homeostasis results in protein misfolding cascades and the accumulation of insoluble protein fibrils and aggregates, such as amyloids. A group of small molecules, traditionally used in histopathology to stain amyloid in tissues, bind protein fibrils and slow aggregation in vitro and in cell culture....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid
• Share to Autophagy
• Share to Benzothiazoles