Article
Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan.
Nature - 14 Apr 2011
Alavez Silvestre, Vantipalli Maithili C, Zucker David J S, Klang Ida M, Lithgow Gordon J
Abstract excerpt
Genetic studies indicate that protein homeostasis is a major contributor to metazoan longevity. Collapse of protein homeostasis results in protein misfolding cascades and the accumulation of insoluble protein fibrils and aggregates, such as amyloids. A group of small molecules, traditionally used...
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