Article

Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease

2023-03-09

Abstract excerpt

<h4>ABSTRACT</h4> Positively charged repeat peptides are emerging as key players in neurodegenerative diseases. These peptides can perturb diverse cellular pathways but a unifying framework for how such promiscuous toxicity arises has remained elusive. We used mass-spectrometry-based proteomics to define the protein targets of these neurotoxic peptides and found that they all share similar sequence features that...

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Literature Corpus work: 2f2bc17c-588e-572f-b49a-bfb5fdc43512
DOI: 10.1101/2023.03.09.531820

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