Article

Mitigating protein aggregation to reduce the toxicity inherent to Parkinson's and Alzheimer's diseases

2018-01-01

Abstract excerpt

Protein deposition in the form of amyloid fibrils is the hallmark of more than 40 human pathologies, including Alzheimer's disease (AD) and Parkinson's disease (PD). Misfolded protein oligomers formed as intermediates during the aggregation process have been strongly implicated in the onset and progression of these diseases. In this thesis, I describe our efforts to uncover molecular agents that can reduce the tox...

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Literature Corpus work: c5fecebf-b5ca-5d19-a502-98f8f85ec1ad
DOI: 10.17863/cam.32308

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