Article

SERF deletion modifies amyloid aggregation in a mouse model of Alzheimer’s disease

2021-01-05

Abstract excerpt

In age-related neurodegenerative disease, like Alzheimer’s and Parkinson’s disease, disease-specific proteins become aggregation-prone and form amyloid-like deposits. Depletion of SERF proteins ameliorates this toxic process in worm- and human cell models for disease. Whether SERF modifies amyloid pathology in mammalian brain, however, has remained unknown. Here, we generated SERF2 brain-specific knockout mice whi...

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Literature Corpus work: c7dc3117-3173-5005-98a5-7d3990bcc765
DOI: 10.1101/2021.01.05.423442

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