Article

Conserved Roles of <i>C. elegans</i> and Human MANFs in Sulfatide Binding and Cytoprotection

2018-02-11

Abstract excerpt

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) is an endoplasmic reticulum (ER) protein that can be secreted and protect dopamine neurons and cardiomyocytes from ER stress and apoptosis. The mechanism of action of extracellular MANF has long been elusive. From a genetic screen for mutants with abnormal ER stress response, we identified the gene Y54G2A.23 as the evolutionarily conserved C. elegans MAN...

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Literature Corpus work: e89abb12-3da2-5945-bb4d-f0e93dc2d0cd
DOI: 10.1101/263731

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