A whole cell luminescence-based screen for inhibitors of the bacterial Sec machinery

Abstract excerpt

There is a pressing need for new antibiotics to combat rising resistance to those already in use. The bacterial general secretion (Sec) system has long been considered a good target for novel antimicrobials thanks to its irreplacable role in maintaining cell envelope integrity; yet the lack of a robust, high-throughput method to screen for Sec inhibition has so far hampered efforts to realise this potential. Here,...

Topics

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• Cell-Free System
• HCT116 Cells
• Macrolides
• Microsomes
• Protein Conformation, alpha-Helical
• Protein Conformation, beta-Strand
• SEC Translocation Channels
• Structural Homology, Protein

Identifiers and source

Literature Corpus work

cd27135f-240e-505d-bc5c-5495b8c7f31f

DOI

10.1101/2024.05.10.593495