Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anniversary of the discovery of sec mutants by Novick and Schekman.

Molecular biology of the cell - 15 May 2015

Spang Anne

Abstract excerpt

This year marks the 35th anniversary of the isolation of 23 SEC genes. These genes all encode key regulators of the secretory pathway, and much of our knowledge of the secretory pathway is based on this initial discovery. The identification of the SEC genes is a result of combining genetics, biochemistry, and electron microscopy in a very clever way. Scientists have been busy ever since seeking to understand the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to History, 20th Century
Share to Molecular Biology
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Saccharomyces cerevisiae

Share to Secretory Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 25972202
DOI: 10.1091/mbc.E14-11-1511
PMCID: PMC4436825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anniversary of the discovery of sec mutants by Novick and Schekman.PMID 25972202Read ↗

The SecY translocation complex: convergence of genetics and structure.Semantic proximity Read ↗

Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway.Semantic proximity Read ↗

Screening a library of temperature-sensitive mutants to identify secretion factors in Staphylococcus aureusSemantic proximity Read ↗

The exocyst subunit Sec3 is regulated by a protein quality control pathway.Semantic proximity Read ↗

SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast.Semantic proximity Read ↗

SEC31A mutation affects ER homeostasis, causing a neurological syndromeSemantic proximity Read ↗

Drosophila sec10 is required for hormone secretion but not general exocytosis or neurotransmission.Semantic proximity Read ↗

A random mutagenesis approach to isolate dominant-negative yeast sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins.Semantic proximity Read ↗

SEC6 exocyst subunit contributes to multiple steps of growth and development of Physcomitrella (Physcomitrium patens).Semantic proximity Read ↗

The Physcomitrella patens exocyst subunit EXO70.3d has distinct roles in growth and development, and is essential for completion of the moss life cycle.Semantic proximity Read ↗

Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosisSemantic proximity Read ↗

Structure-function study of the N-terminal domain of exocyst subunit Sec3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.