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Identification of Small-Molecule Inhibitors of Yersinia pestis Type III Secretion System YscN ATPase

18 May 2011

Abstract excerpt

Yersinia pestis is a gram negative zoonotic pathogen responsible for causing bubonic and pneumonic plague in humans. The pathogen uses a type III secretion system (T3SS) to deliver virulence factors directly from bacterium into host mammalian cells. The system contains a single ATPase, YscN, necessary for delivery of virulence factors. In this work, we show that deletion of the catalytic domain of the yscN gene...

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PMID: 21611119
DOI: 10.1371/journal.pone.0019716

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