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Article

A High-Throughput Approach To Identify Compounds That Impair Envelope Integrity in Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Oct 2016

Baker Kristin R, Jana Bimal, Franzyk Henrik, Guardabassi Luca

Abstract excerpt

The envelope of Gram-negative bacteria constitutes an impenetrable barrier to numerous classes of antimicrobials. This intrinsic resistance, coupled with acquired multidrug resistance, has drastically limited the treatment options against Gram-negative pathogens. The aim of the present study was to develop and validate an assay for identifying compounds that increase envelope permeability, thereby conferring...

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Identifiers

PMID: 27458225
DOI: 10.1128/AAC.00537-16
PMCID: PMC5038306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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