Article

H3K27M Mutation Reshapes the Antigenic Landscape in Diffuse Midline Glioma

2025-04-10

Abstract excerpt

<h4>Simple Summary</h4> Diffuse midline gliomas (DMGs) are aggressive childhood brain tumours with no effective treatments. Over 80% of cases carry the histone H3K27M mutation, which alters chromatin structure and gene regulation and induce tumours growth. Immunotherapy, which uses the body’s immune system to fight cancer, relies on tumour- specific antigen molecules that immune cells can recognise. However, beca...

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Literature Corpus work: f6c3b29a-1a2e-5099-8383-869a566934c5
DOI: 10.1101/2025.04.07.647502

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