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A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell-of-origin dependent effects of H3K27M.

Glia - 1 Sept 2022

Tomita Yusuke, Shimazu Yosuke, Somasundaram Agila, Tanaka Yoshihiro, Takata Nozomu, Ishi Yukitomo, Gadd Samantha, Hashizume Rintaro, Angione Angelo, Pinero Gonzalo, Hambardzumyan Dolores, Brat Daniel J, Hoeman Christine M, Becher Oren J

Abstract excerpt

Diffuse midline glioma (DMG) is a type of lethal brain tumor that develops mainly in children. The majority of DMG harbor the K27M mutation in histone H3. Oligodendrocyte progenitor cells (OPCs) in the brainstem are candidate cells-of-origin for DMG, yet there is no genetically engineered mouse model of DMG initiated in OPCs. Here, we used the RCAS/Tv-a avian retroviral system to generate DMG in Olig2-expressing...

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Identifiers

PMID: 35524725
DOI: 10.1002/glia.24189
PMCID: PMC9546478

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