Article

Oncohistone inhibition reshapes tumor–microenvironment communication in Diffuse Midline Glioma (DMG)

2026-06-18

Abstract excerpt

<h4>Background</h4> Diffuse midline glioma (DMG) is a lethal pediatric brain tumor driven by the H3K27M oncohistone, which disrupts epigenetic regulation and promotes tumor proliferation. While prior studies show that H3K27M is essential for tumor initiation, its role in established tumors, tumor microenvironment (TME) regulation, and therapeutic response remain unclear. <h4>Methods</h4> Here, we developed induc...

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Identifiers and source

Literature Corpus work: b805652f-42b5-50bb-a99f-5248b568c791
DOI: 10.64898/2026.06.17.731637

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