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Article

H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions.

Cells - 28 Jun 2024

Nonnenbroich Leo F, Bouchal Samantha M, Millesi Elena, Rechberger Julian S, Khatua Soumen, Daniels David J

Abstract excerpt

Pediatric high-grade gliomas are a devastating subset of brain tumors, characterized by their aggressive pathophysiology and limited treatment options. Among them, H3 K27-altered diffuse midline gliomas (DMG) of the brainstem stand out due to their distinct molecular features and dismal prognosis. Recent advances in molecular profiling techniques have unveiled the critical role of H3 K27 alterations, particularly...

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Identifiers

PMID: 38994974
DOI: 10.3390/cells13131122
PMCID: PMC11240752

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