Article
Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence.
American journal of medical genetics - 9 Oct 2000
Silverman M A, Neale M C, Sullivan P F, Harris-Kerr C, Wormley B, Sadek H, Ma Y, Kendler K S, Straub R E
Abstract excerpt
Several types of evidence, including experiments with mice that lack the nicotinic acetylcholine receptor beta2-subunit gene (CHRNB2), have suggested that a beta2-containing nicotinic receptor is necessary for at least some of the reinforcing properties of nicotine. However, sequence variations in CHRNB2 have not been reported, and its role in influencing human smoking behavior and nicotine dependence is not...
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