Article

Pharmacological inhibition of D-serine biosynthesis improves hippocampal memory, prevents neuronal loss and enhances synaptic connectivity in a mouse model of Alzheimer's disease

2025-07-08

Abstract excerpt

<h4>Background: </h4> and Purpose: N-methyl-D-aspartate receptors (NMDARs) have been involved in the neurotoxic effects of amyloid-β (Aβ) in Alzheimer’s disease (AD). The aim of this study was to evaluate the effects of reducing the generation of the NMDAR co-agonist D-Serine (D-Ser), by pharmacological inhibition of serine racemase (SR) in a mouse model of amyloidosis. Additionally, to determine the expression pa...

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Literature Corpus work: ccf1b401-46ba-5633-90a7-3a99300add81
DOI: 10.22541/au.175196785.52746844/v1

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