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Article

APOE-ε4 genotype and western diet synergistically aggravate synaptic dysfunction in Alzheimer's disease via D-serine disruption.

Alzheimer's research & therapy - 25 Feb 2026

Matos M, Oliveira A, Matias I, Le Boulch A, Ciofi P, Dupuy L, Huc E, Oliet S H R, Panatier A

Abstract excerpt

BACKGROUND: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder thought to result from complex interactions between genetic and environmental risk factors. The APOE-ε4 allele is the strongest genetic contributor to late-onset AD, while a Western diet - high in saturated fats and refined sugars - is a major lifestyle-related risk factor associated with AD progression. However, how these two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41736084
DOI: 10.1186/s13195-026-01992-y
PMCID: PMC13041213

Genes

APOE
APP
CA1
CA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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