L-norvaline reverses cognitive decline and synaptic loss in a murine model of Alzheimer’s disease

Abstract excerpt

The urea cycle plays a role in the pathogenesis of Alzheimer’s disease (AD). Arginase-I accumulation at sites of amyloid-beta deposition is associated with L-arginine deprivation and neurodegeneration. Moreover, a positive interaction between the arginase-II and mTOR-S6K1 pathways promote inflammation and oxidative stress. In this study, we treated 3xTg-AD mice exhibiting increased ribosomal protein S6 kinase beta...

Topics

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• Amyloid beta-Protein Precursor
• Arginine
• Immunologic Factors
• Maze Learning
• Memory, Short-Term
• Microarray Analysis
• Microglia
• Nitric Oxide Synthase Type II

Identifiers and source

Literature Corpus work

8b4bdd15-6c0f-5f6f-9124-d374624cf970

DOI

10.1101/354290