Back to search

Article

Targeting N‐methyl‐D‐aspartate Receptors in Neurodegenerative Diseases

2024-02-12

Abstract excerpt

N-methyl-D-aspartate receptors (NMDARs) are the main class of ionotropic receptor for the ex-citatory neurotransmitter glutamate. It plays a crucial role in the permeability of Ca2+ ions and excitatory neurotransmission in the brain. Being heteromeric receptors, they are composed of sev-eral subunits, including two obligatory GluN1 subunits (eight splice variants) and regulatory GluN2 (GluN2A~D) and/or GluN3 (GluN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ca43c4c2-9fd7-50dc-991c-d94631453b04
DOI
10.20944/preprints202402.0679.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeting N‐methyl‐D‐aspartate Receptors in Neurodegenerative DiseasesDOI 10.20944/preprints202402.0679.v1
Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer’s Disease, a Potential Therapeutic TargetSemantic proximity
Specific Roles of NMDA Receptor Subunits in Mental Disorders.Semantic proximity
Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer’s DiseaseSemantic proximity
7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo.Semantic proximity
Neuroprotective strategies for NMDAR-mediated excitotoxicity in Huntington’s DiseaseSemantic proximity
The role of metabotropic glutamate receptors in Alzheimer's diseaseSemantic proximity
Identification of novel allosteric modulator binding sites in NMDA receptors: A molecular modeling study.Semantic proximity
Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer’s DiseaseSemantic proximity
Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an updateSemantic proximity
Downstream allosteric modulation of NMDA receptors by 3-benzazepine derivativesSemantic proximity
NMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease ModelsSemantic proximity
Metabotropic glutamate receptor involvement in the pathophysiology of amyotrophic lateral sclerosis: new potential drug targets for therapeutic applicationsSemantic proximity
Select a neighboring publication to make it the new centre.