Article

The ketamine metabolite ( <i>2R,6R</i> )-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer’s disease

2023-08-03

Abstract excerpt

Impaired synaptic plasticity and progressive memory deficits are major hallmarks of Alzheimer’s disease (AD). Hippocampal mRNA translation, required for memory consolidation, is defective in AD. Here, we show that systemic treatment with ( 2R,6R )- hydroxynorketamine (HNK), an active metabolite of the antidepressant ketamine, prevented deficits in hippocampal mRNA translation, long-term potentiation (LTP) and mem...

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Literature Corpus work: ff7d9534-07f5-5013-a293-9c041c5657a6
DOI: 10.1101/2023.08.03.551808

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