Article

APOE-ε4 Genotype and Western Diet Synergistically Aggravate Synaptic Dysfunction in Alzheimer’s Disease via D-serine Disruption

2025-08-27

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Alzheimer’s disease (AD) is a progressive neurodegenerative disorder thought to result from complex interactions between genetic and environmental risk factors. The APOE-ε4 allele is the strongest genetic contributor to late-onset AD, while a Western diet - high in saturated fats and refined sugars - is a major lifestyle-related risk factor associated with AD...

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Literature Corpus work: 446d82f5-ab0a-51b0-bd08-1b7731f2261a
DOI: 10.21203/rs.3.rs-7320776/v1

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