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Article

Reversal of tau-dependent cognitive decay by blocking adenosine A1 receptors in mouse models of tauopathy

2022-02-21

Abstract excerpt

<h4>Background: </h4> Accumulation of tau is a characteristic hallmark of several neurodegenerative diseases and is associated with neuronal hypoactivity and presynaptic dysfunction. Oral administration of the adenosine A 1 receptor antagonist rolofylline (KW-3902) has been shown previously to reverse spatial memory deficits and to normalize the basic synaptic transmission in a mouse line expressing full-length pr...

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Literature Corpus work
9f3c95d2-50ae-5670-8193-b6181ea34427
DOI
10.21203/rs.3.rs-1363420/v1
Open publication

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Reversal of tau-dependent cognitive decay by blocking adenosine A1 receptors in mouse models of tauopathyDOI 10.21203/rs.3.rs-1363420/v1
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