Article

CBL mutations in pediatric solid and CNS tumors are a marker of receptor tyrosine kinase activation and a potential therapeutic target

2025-12-05

Abstract excerpt

Mutations in CBL , an E3 ubiquitin ligase that negatively regulates receptor tyrosine kinases (RTKs) and potentiates intracellular signaling, have been extensively characterized in hematological malignancies. However, the impacts are unknown in other cancer types. We have identified established and novel aberrations in CBL in molecularly diverse pediatric CNS and solid tumors. Additionally, we present novel CBL...

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Literature Corpus work: cce77d8f-a6da-5a16-98c5-5a2e919dc8f9
DOI: 10.64898/2025.12.02.691063

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