Article
Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.
Cell cycle (Georgetown, Tex.) - 15 Mar 2010
Ogawa Seishi, Sanada Masashi, Shih Lee-Young, Suzuki Takahiro, Otsu Makoto, Nakauchi Hiromitsu, Koeffler H Philip
Abstract excerpt
c-CBL (CBL) encodes a multifunctional protein engaged in the regulation of intracellular signaling pathways. It was first identified as a cellular counterpart of the viral oncogene, v-CBL, that causes murine lymphoma. Although no genetic evidence existed suggesting its role in human carcinogenesis, the recent discovery of c-CBL mutations in myeloid cancers has unveiled a unique oncogenic mechanism mediated by...
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