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Article

E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.

Blood - 5 Nov 2009

Bandi Srinivasa Rao, Brandts Christian, Rensinghoff Marion, Grundler Rebekka, Tickenbrock Lara, Köhler Gabriele, Duyster Justus, Berdel Wolfgang E, Müller-Tidow Carsten, Serve Hubert, Sargin Bülent

Abstract excerpt

Somatic mutations of Kit have been found in leukemias and gastrointestinal stromal tumors. The proto-oncogene c-Cbl negatively regulates Kit and Flt3 by its E3 ligase activity and acts as a scaffold. We recently identified the first c-Cbl mutation in human disease in an acute myeloid leukemia patient, called Cbl-R420Q. Here we analyzed the role of Cbl mutants on Kit-mediated transformation. Coexpression of...

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Identifiers

PMID: 19734451
DOI: 10.1182/blood-2008-12-190934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.PMID 19734451Read ↗

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