Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting.

PloS one - 1 Jan 2024

Lim Kelly, Kan Winnie L, Nair Pramod C, Kutyna Monika, Lopez Angel F, Hercus Timothy, Ross David M, Lane Steven, Fong Chun Yew, Brown Anna, Yong Agnes, Yeung David, Hughes Timothy, Hiwase Devendra, Thomas Daniel

Abstract excerpt

Chronic myelomonocytic leukemia (CMML) is a rare blood cancer of older adults (3 in every 1,000,000 persons) characterized by poor survival and lacking effective mutation-specific therapy. Mutations in the ubiquitin ligase Cbl occur frequently in CMML and share biological and molecular features with a clonal disease occurring in children, juvenile myelomonocytic leukemia (JMML). Here we analyzed the clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dioxygenases

Share to DNA-Binding Proteins

Share to Leukemia, Myelomonocytic, Chronic

Share to Leukemia, Myelomonocytic, Juvenile

Share to Mutation

Share to Proto-Oncogene Proteins c-cbl

Source

Open in PubMed Open full text

Identifiers

PMID: 39298477
DOI: 10.1371/journal.pone.0310641
PMCID: PMC11412512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting.PMID 39298477Read ↗

Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.Semantic proximity Read ↗

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemiaSemantic proximity Read ↗

Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia.Semantic proximity Read ↗

Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia.Semantic proximity Read ↗

Mutations of c-Cbl in myeloid malignancies.Semantic proximity Read ↗

Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemiaSemantic proximity Read ↗

CBL mutations in pediatric solid and CNS tumors are a marker of receptor tyrosine kinase activation and a potential therapeutic targetSemantic proximity Read ↗

Juvenile myelomonocytic leukemia: who’s the driver at the wheel?Semantic proximity Read ↗

Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia.Semantic proximity Read ↗

A child with juvenile myelomonocytic leukemia possessing a concurrent germline CBL mutation and a NF1 variant of uncertain significance: A rare case with a common problem in the era of high-throughput sequencing.Semantic proximity Read ↗

Mutations of the TET2 and CBL genes: novel molecular markers in myeloid malignancies.Semantic proximity Read ↗

Morphologic and Immunophenotypic Differences in Juvenile Myelomonocytic Leukemias With CBL and Other Canonical RAS-pathway Gene Mutations: A Single Institutional Experience.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.