Article

CBL mutations promote activation of PI3K/AKT signaling via LYN kinase

2020-04-14

Abstract excerpt

CBL encodes an E3 ubiquitin ligase and signaling adaptor that acts downstream of cytokine receptors. Recurrent CBL mutations occur in myeloid malignancies, but the mechanism by which these mutations drive oncogenesis remains incompletely understood. Here we performed a series of studies to define the phosphoproteome, CBL interactome and molecular mechanisms of signaling activation in cells expressing an allelic s...

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Literature Corpus work: 33e77fee-ca58-54b9-a60d-75bb1c066588
DOI: 10.1101/2020.04.13.038448

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